| Zvanje: | izvanredni profesor |
| Lokacija: | 306/ZBK |
| Telefon: | +385 1 4606 232 |
| Telefon kućni: | 6232 |
| E-mail: | |
| URL službenih stranica na Webu: | http://www.pmf.unizg.hr/chem/jasmina.rokov_plavec |
| Zavod/služba: | Zavod za biokemiju |
| Godina diplomiranja: | 1994. |
| Godina magistriranja: | 1998. |
| Godina doktoriranja: | 2004. |
| Na zavodu od: | 1995. |
prijediplomski
diplomski
integrirani prijediplomski i diplomski
doktorski
Jasmina Rokov Plavec je diplomirala 1994. (dipl. inž. biologije, smjer molekularna biologija), magistrirala 1998. (magistar prirodnih znanosti, polje biologija) te doktorirala 2004. (doktor prirodnih znanosti, polje biologija) na PMF-u Sveučilišta u Zagrebu. Doktorsku disertaciju pod naslovom Organelna seril-tRNA-sintetaza iz kukuruza: karakterizacija in vitro i in vivo izradila je pod voditeljstvom prof. dr. sc. Ivane Weygand-Đurašević.
Od 1995. zaposlena je na Kemijskom odsjeku PMF-a, a od 2024. radi na mjestu izvanredne profesorice. Usavršavala se na Central European Institute of Technology, Brno, Češka (dva tjedna 2019.), Institut de Biologie Moléculaire des Plantes du CNRS, Strasbourg, Francuska (dva mjeseca 2006.) te Yale University, New Haven, SAD (dva mjeseca 1999.).
Istražuje strukturu, funkciju i evoluciju aminoacil-tRNA-sintetaza, s osobitim naglaskom na biljne seril-tRNA-sintetaze (SerRS). Zanima ju unutarstanični smještaj proteina, uloga biljne SerRS u staničnom odgovoru biljne stanice na okolišni stres, te identifikacija proteinskih partnera biljne SerRS. Osim toga, istražuje ulogu pogrešaka u translaciji na adaptaciju bakterija stanica na oksidacijski stres.
Dosad je objavila 19 znanstvenih radova, 2 stručna rada, 2 poglavlja u sveučilišnom udžbeniku i 3 praktikumska skripta. Sudjelovala je na znanstvenim sastancima (4 pozvana predavanja, 10 sekcijskih predavanja, 33 posterska priopćenja).
Nositeljica je 5 kolegija na preddiplomskim i diplomskim studijima PMF-a, te 2 kolegija na doktorskom studiju kemije PMF-a. Bila je voditeljica dvije doktorske disertacije, 12 diplomskih radova, 38 završnih radova, te neposredna voditeljica 6 diplomskih radova.
Godine 1993. dobila je Rektorovu nagradu SuZ-a. Od 1997. članica je Hrvatskog društva za biokemiju i molekularnu biologiju, a od 2013. do 2021. članica Izvršnog odbora istog društva. Godine 1997./1998. bila je suvoditeljica Mladih istraživača, sekcije Hrvatskog prirodoslovnog društva. Od 2013. do 2018. bila je članica Povjerenstva za nastavu Kemijskog odsjeka. Od 2018. do 2020. bila je predstojnica Zavoda za biokemiju. Od 2021. voditeljica je Laboratorija za enzimsku kinetiku i preparativnu biokemiju u okviru Centra izvrsnosti u kemiji (CIuK) na Kemijskom odsjeku PMF-a. Od 2021. članica je Povjerenstva za upravljanje kvalitetom PMF-a.
Protein–Protein Interactions of Seryl-tRNA Synthetases with Emphasis on Human Counterparts and Their Connection to Health and Disease
Interplay of isoleucine mistranslation and oxidative stress from a proteomic perspective
Proteomic Analysis of the Role of Isoleucine Mistranslation in the Adaptation of Escherichia coli to Oxidative Stress
Disulfide link in plant cytosolic aminoacyl-tRNA synthetase is implicated in oxidative stress response
Laboratory course “From gene to recombinant protein“
Disulfide bond enables cytosolic protein to function in oxidizing conditions
Međuigra mistranslacije i oksidacijskog stresa u bakteriji Escherichia coli
Evolutionarily conserved cysteines in plant cytosolic seryl-tRNA synthetase are important for its resistance to oxidation
The role of disulfide bond in the plant cytosolic seryl-tRNA synthetase
Beneficial effect of mistranslation on proliferation and viability of bacteria Escherichia coli in oxidative stress
Mistranslation helps Escherichia coli to adapt to oxidative stress
The role of mistranslation in oxidative stress response in bacteria Escherichia coli
Contrasting effect of evolutionary conserved cysteines on the stability of plant seryl-tRNA synthetase
Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study
Emerging noncanonical functions of plant aminoacyl- tRNA synthetase
Influence of mistranslation stress on oxidative stress response in bacteria Escherichia coli
Importance of protein intrinsic conformational dynamics and transient nature of non-covalent interactions in ligand binding affinity
Effect of mistranslation and oxidative stress on growth and viability of bacteria Escherichia coli
Expression of genes for selected plant aminoacyl-tRNA synthetases in the abiotic stress
Importance of the disulfide link in the stability of cytosolic protein
Plant seryl-tRNA synthetase as a link between translation and metabolism of brassinosteroid hormones
Is expression of VEGFA gene regulated by seryl-tRNA synthetase in renal cell carcinoma?
Plant seryl-tRNA synthetase as a link between translation and metabolism of brassinosteroid hormones
Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase
Where translation meets plant steroid metabolism: interaction of seryl-tRNA synthetase and BEN1 protein from Arabidopsis thaliana
Revealing the structure of the first plant aminoacyl-tRNA synthetase at 2.3 Å
Seryl-tRNA synthetase: potential link between translation and metabolism of brassinosteroid hormones
Plant aminoacyl-tRNA synthetases in abiotic stress
The first crystal structure of plant aminoacyl-tRNA synthetase: seryl-tRNA synthetase from Arabidopsis thaliana
Dysregulation of seryl-tRNA synthetase in kidney disease
Protein design
Interplay of proteins involved in translation and steroid hormone metabolism in Arabidopsis
Advanced Laboratory of Chemistry
Exclusive cytosolic localization and broad tRNASer specificity of Arabidopsis thaliana seryl-tRNA synthetase
Seryl-tRNA Synthetases in Translation and Beyond
Book of Abstracts of the Symposium and Workshop on Microscale Thermophoresis
Strukturna istraživanja proteinskog kompleksa atipične seril-tRNA-sintetaze
Plant seryl-tRNA synthetase and metabolic protein BEN1: identification of interaction surfaces by biophysical methods
Fluorescence approach for determination of ribosomal L12 protein binding domains involved in interaction with seryl-tRNA synthetase
Analysis of protein interactions using fluorescence technologies
Pinpointing the interaction domains of plant seryl- tRNA synthetase and metabolic protein BEN1
Noncanonical interactions of plant seryl-tRNA synthetase
Arabidopsis thaliana seryl-tRNA synthetase participates in cellular stress response
Interaction of plant seryl-tRNA synthetase and BEN1, protein involved in brassinosteroid metabolism
In vivo and in vitro analysis of plant seryl-tRNA synthetase interactome
Substrate recognition and fidelity of maize seryl- tRNA synthetases
Arabidopsis thaliana cytosolic seryl-tRNA synthetase: studying protein-protein interactions
Plant seryl-tRNA synthetases : fidelity and macromolecular recognition
Dual targeting of organellar seryl-tRNA synthetase to maize mitochondria and chloroplasts
Nobel prize for chemistry for year 2008
Structural flexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for specific substrate recognition
Isolation of mitochondria from potato tuber
Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain
Isolation of tRNA
Amber suppression in bacterium Escherichia coli using archaeal ortologous seryl-tRNA
Stability of the complex between yeast seryl- tRNA synthetase and tRNASer under different electrophoretic conditions
Unilateral flexibility in tRNASer recognition by heterologous seryl-tRNA synthetases
In vivo recognition of eukaryal and bacterial tRNAsSer by heterologous seryl-tRNA synthetases
Seryl-tRNA syntheases: Structure, function and evolution across all three domains of life
Maize seryl-tRNA synthetase: specificity of substrate recognition by the organellar enzyme
Organellar and cytosolic seryl-tRNA synthetases: structural, functional and evolutionary aspects
Structure, function and evolution of aminoacyl-tRNA synthetases
Evolution of determinants in seryl-tRNA synthesis
SUSTAV ZA AMINOACILACIJU tRNA: OBLIKOVANJE STRUKTURA MAKROMOLEKULA I SPECIFIČNOSTI NJIHOVIH INTERAKCIJA
Seryl-tRNA synthesis in maize
Phylogenetic relationships and early evolutionary events in seryl-tRNA synthetases
Cloning and expression of the gene for seryl-tRNA synthetase from maize Zea mays
MAIZE SERYL-tRNA SYNTHETASES FROM DIFFERENT CELLULAR COMPARTMENTS
Functional and evolutionary analysis of organellar seryl-tRNA synthetases
MITOCHONDRIAL AND CYTOPLASMIC SERYL-tRNA SYNTHETASES FROM Zea mays
Maize mitochondrial seryl-tRNA synthetase recorgnizes Escherichia coli tRNASer in vivo and in vitro
tRNA dependent amino acid recognition by yeast seryl-tRNA synthetase
Strutural and functional relationship among cytoplasmic and mitochondrial seryl-tRNA synthetases
SerZMo gene codes for maize organellar seryl-tRNA synthetase
1. Dulic M, Godinic-Mikulcic V, Kekez M, Evic V, Rokov-Plavec J*. Protein–Protein Interactions of Seryl-tRNA Synthetases with Emphasis on Human Counterparts and Their Connection to Health and Disease. Life 2024; 14(124) 1-23. doi: 10.3390/life14010124 *dopisni autor
2. Evic V, Soic R, Mocibob M, Kekez M, Houser J, Wimmerová M, Matković-Čalogović D, Gruic-Sovulj I, Kekez I*, Rokov-Plavec J*. Evolutionarily conserved cysteines in plant cytosolic seryl-tRNA synthetase are important for its resistance to oxidation. FEBS Lett. 2023;597(23):2975-2992. doi: 10.1002/1873-3468.14748. *dopisni autor
3. Kekez M, Zanki V, Antičević I, Rokov-Plavec J*, Maršavelski A*. Importance of protein intrinsic conformational dynamics and transient nature of non-covalent interactions in ligand binding affinity. Int J Biol Macromol. 2021;192:692-700. doi: 10.1016/j.ijbiomac.2021.10.045.
4. Baranašić J, Mihalak A, Gruić-Sovulj I, Bauer N, Rokov-Plavec J*. Expression of genes for selected plant aminoacyl-tRNA synthetases in the abiotic stress. Acta Botanica Croatica 2021; 80(1):35-42. doi:10.37427/botcro-2021-010 *dopisni autor
5. Kekez M, Zanki V, Kekez I, Baranasic J, Hodnik V, Duchêne A-M, Anderluh G, Ita Gruić-Sovulj I, Matković-Čalogović D, Weygand-Đurašević I, Rokov-Plavec J*. Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase. FEBS J. 2019; 286 (3): 536-554. (https://rdcu.be/bfhc1) *dopisni autor
Voditeljstvo projekta:
1. Projekt razvoja karijera mladih istraživača - izobrazba novih doktora znanosti (DOK-2018-09-1578), financiranje: HRZZ, razdoblje: 2019. – 2024., mentorica HRZZ doktoranda
2. Funkcijska i strukturna karakterizacija proteinskih kompleksa biljne aminoacil-tRNA-sintetaze, financiranje: Zaklada HAZU, razdoblje: 2018. - 2019.
3. Povezanost biosinteze proteina i metabolizma steroidnih hormona kod biljaka, financiranje: Zaklada HAZU, razdoblje: 2016. - 2017.
4. Uloga biljne aminoacil-tRNA-sintetaze u staničnom odgovoru na stres, financiranje: Zaklada HAZU, razdoblje: 2014. - 2015.
Suvoditeljica radne skupine:
1. INTEGRA-LIFE, financiranje: EU, FP7-REGPOT, voditelj: prof. dr. sc. Gordan Lauc, 2013. - 2016.
Suradnica na projektima:
1. Aminoacil-tRNA-sintetaze kao čuvari standardnog genetičkog koda, financiranje: HRZZ, voditelj: prof. dr. sc. Ita Gruić Sovulj, 2017. - 2021.
2. COST Action CA15126 Between Atom and Cell: Integrating Molecular Biophysics Approaches for Biology and Healthcare (MOBIEU), voditelj: Dr. Patrick England, 2016. – 2020.
3. Nekanonske uloge aminoacil-tRNA-sintetaza, financiranje: HRZZ, voditelji: prof. dr. sc. Ivana Weygand-Đurašević, izv. prof. dr. sc. Ita Gruić Sovulj, 2013. - 2016.
4. Makromolekularni kompleksi aminoacil-tRNA-sintetaza i njihova uloga u kontroli ribosomske i neribosomske biosinteze proteina, financiranje: UKF, voditelj: prof. dr. sc. Ivana Weygand-Đurašević, 2007. – 2010.
5. Strukturna raznolikost seril-tRNA-sintetaza i točnost biosinteze proteina, financiranje: MZOS; voditelj: prof. dr. sc. Ivana Weygand-Đurašević, 2007. - 2014.
6. Seril-tRNA-sintetaze: mehanizmi i kontrola serilacije u biosintezi proteina, MZOS; voditelj: prof. dr. sc. Ivana Weygand-Đurašević, 2002. - 2007.
7. Struktura, funkcija i evolucija aminoacil-tRNA-sintetaza, MZOS; voditelj: prof. dr. sc. Ivana Weygand-Đurašević, 1996. - 2002.
Pristupačnost
