| Zvanje: | izvanredni profesor |
| Lokacija: | 307a/ZBK |
| Telefon: | +385 1 4606 241 |
| Telefon kućni: | 6241 |
| E-mail: | |
| Zavod/služba: | Zavod za biokemiju |
| Godina diplomiranja: | 2010. |
| Godina magistriranja: | 2011. |
| Godina doktoriranja: | 2017. |
| Na zavodu od: | 2018. |
prijediplomski
diplomski
integrirani prijediplomski i diplomski
Stipendije i nagrade
2023. Woman in Research (WiRe) postdoktorska stipendija, Sveučilište u Münsteru, SR Njemačka
2017. Godišnja nagrada Društva sveučilišnih nastavnika i drugih znanstvenika u Zagrebu
2016. – 2017. Stipendija Grada Zagreba doktorandima studija u gradu Zagrebu
2016. Godišnja nagrada Instituta Ruđer Bošković za izvrstan znanstveni rad za 2015. godinu
2016. FEBS Short-Term stipendija za znanstveno istraživački posjet laboratoriju prof. Lynn Kamerlin na Sveučilištu u Uppsali, Švedska
Usavršavanja u inozemstvu
08-10/2019 boravak u sklopu UKF projekta, Uppsala Biomedical Center, Department of Cell and Molecular Biology, Sveučilište u Uppsali, Uppsala, Švedska
08-09/2017. usavršavanje u području analize koreliranih gibanja proteina, Research School of Chemistry, The Australian National University, Canberra, Australija
06–08/2016. usavršavanje u području EVB simulacija enzimski kataliziranih reakcija, Uppsala Biomedical Center, Department of Cell and Molecular Biology, Sveučilište u Uppsali, Uppsala, Švedska
01-02/2016. usavršavanje u području EVB simulacija enzimski kataliziranih reakcija, Laboratory of Computational Biochemistry and Drug Design, National Institute of Chemistry, Ljubljana, Slovenija)
PROJEKTI
Voditeljica
• ”Enzimsko inženjerstvo za održivo recikliranje bioplastike“, Razvojne istraživačke potpore, Nacionalni plan oporavka i otpornosti, Next Generation EU, lipanj 2023 – spranj 2026.
• „Sustainable Management of Plastic Waste through Biorecycling“, 1. travnja 2023 –31. ožujka 2024. Financiran kroz Horizon2020 program UNIC 4 Engaged Research (UNIC4ER); Projekt za uspostavu konzorcija i kolaborativne mreže
• Projekt u okviru WiRe stipendije „Ancestral protein reconstruction for developing enzymes for degrading environment polluting bioplastics“ 2023, Sveučilište u Münsteru, SR Njemačka
• “Computational optimization of enzymes that catalyse beneficial reactions for the environment” 2021-2022, Zaklada Hrvatske Akademije Znanosti i Umjetnosti
• “Characteristics of the primordial amino acid norvaline in the context of modern proteins” 2020-2021, Zaklada Hrvatske Akademije Znanosti i Umjetnosti
• “Catalytic selectivity toward fluorinated compounds” u suradnji s Prof. Shina Caroline Lynn Kamerlin, Sveučilište u Uppsali, Uppsala, Švedska 2019, Unity through knowledge Fund (UKF)
• “Mechanisms of discrimination in editing domain of isoleucyl-tRNA synthetase from E. coli” 2019-2020, Zaklada Hrvatske Akademije Znanosti i Umjetnosti
Sudjelovanje na projektima
COST Action CA21162 – “Establishing a Pan-European Network on Computational Redesign of Enzymes” (2022-2026) – sekundarni prijavitelj, MC član i voditeljica WG2 Computational optimization of catalytic properties
COST Action CA21160 - “Non-globular proteins in the era of Machine Learning (2022-2026) - MC član
“HERO – Healthcare Online”; EU project – Central European Initiative (CEI) – 2020-2021
Suradnica na projektu Alosterički komunikacijski putevi u oligomernim enzimima; (2019-2023) Hrvatska zaklada za znanost
Suradnica (konzultant) na projektu Aminoacil-tRNA-sintetaze kao čuvari standardnog genetičkog koda (2017-2021); Hrvatska zaklada za znanost
Suradnica na projektu Computational studies of the biogenic amines of the brain for targeting neurological diseases – CompBAND (2013-2017); FP7 Marie Curie Career Integration Grant
Di-mannosylation enhances the adjuvant properties of adamantane-containing desmuramyl peptides in vivo
Thermal and structural characterization of selected biopolymers after irradiation
MDavocado: Analysis and Visualization of Protein Motion by Time-Dependent Angular Diagrams
Book of Abstracts: COZYME2024
HOW DID NEGATIVE CATALYSIS TAILOR THE SPECIFICITY OF ISOLEUCYL-tRNA SYNTHETASES’S EDITING DOMAIN?
Primjena metagenomskih esteraza za okolišno prihvatljivu razgradnju polimliječne kiseline
Computational analysis of purine nucleoside phosphorylase dynamics
Računalna i eksperimentalna karakterizacija esteraze iz Rhodopseudomonas palustris za razgradnju polimliječne kiseline
DECIPHERING DYNAMICS OF PURINE NUCLEOSIDE PHOSPHORYLASE
Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Estimating risk of cardiovascular pharmaceuticals in freshwaters using zebrafish embryotoxicity test - statins threat revealed
Allosteric Communication in Enzymes Through Advanced Visualization of MD Simulations
Impact of non-proteinogenic amino acid norvaline and proteinogenic valine misincorporation on a secondary structure of a model peptide
Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases
NEGATIVE CATALYSIS BY ISOLEUCYL-tRNA SYNTHETASE: HOW BROAD SUBSTRATE SELECTIVITY DOES NOT PROMOTE FUTILE EDITING CYCLES
ALL BUT ONE: HOW NEGATIVE CATALYSIS SHAPED EVOLUTION OF THE ISOLEUCYL-TRNA SYNTHETASE'S EDITING DOMAIN
Search for Allostery in Purine Nucleoside Phosphorylases via Database of Molecular Interactions
Why monoamine oxidase B preferably metabolizes N-methylhistamine over histamine: evidence from the multiscale simulation of the rate-limiting step
The EVB method: in silico approach to understanding the enzyme catalysis
Mannosylated adamantane-containing desmuramyl peptide recognition by the NOD2 receptor: a molecular dynamics study
Synthesis of immunostimulating mannosylated desmuramyl peptides and a structural insights into NOD2 binding
Adamantane-containing desmuramyl peptides: synthesis and structural insight into NOD2 binding
Importance of protein intrinsic conformational dynamics and transient nature of non-covalent interactions in ligand binding affinity
Understanding substrate promiscuity by computational approach: a case study of selected phospholipase and lipase
Optimized SQE atomic charges for peptides accessible via a web application
Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires
Nanosized zeolite beta - determining the safety of usage by zebrafish Danio rerio embryos
The substrate selectivity of the two homologous SGNH hydrolases from Streptomyces bacteria: Molecular dynamics and experimental study
Mechanism of action of diphtheria and cholera toxins
Heparanase binds substrate via a dynamic binding mechanism
Computational approach to substrate promiscuity: a case study of selected phospholipase and lipase enzymes
Laureates of the Society's Annual Awards
Computational modeling of histamine metabolism in humans
Expanded and revisited mode of action of antibiotics pantothenamides
4th International Scientific Meeting of COST Action CM1306 “Understanding Movement and Mechanism in Molecular Machines”, Book of Abstracts, Zagreb, 21-24, March, 2018
Empirical Valence Bond Simulations Suggest a Direct Hydride Transfer Mechanism for Human Diamine Oxidase
Računalno ispitivanje katalitičke aktivnosti i selektivnosti aminskih oksidaza prema histaminu i N-metilhistaminu
What a difference a methyl group makes - the selectivity of monoamine oxidase B towards histamine and N-methylhistamine
Catalytic Dyad in the SGNH Hydrolase Superfamily: In-depth Insight into Structural Parameters Tuning the Catalytic Process of Extracellular Lipase from Streptomyces rimosus
15N NMR Spectroscopy, X-ray and Neutron Diffraction, Quantum-Chemical Calculations, and UV/vis-Spectrophotometric Titrations as Complementary Techniques for the Analysis of Pyridine-Supported Bicyclic Guanidine Superbases
Computational study of the substrate specificity of monoamine oxidase B
A novel antimicrobial target—expanded and revisited mode of action of pantothenamides
Computational study of the substrate specificity of monoamine oxidase B
The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands
Computational Insights into Substrate Specificity of Monoamine Oxidase B
Synthesis and characterization of ML and ML2 metal complexes with amino acid substituted bis(2-picolyl)amine ligands
Computational study of the substrate specificity of monoamine oxidase B
Computational investigations of the B. japonicum Gly:CP ligase 1 specificity towards amino acid substrate and aminoacyl carrier protein
Supramolecular Ionic-Liquid Gels with High Ionic Conductivity
The binding of histamine and N-methylhistamine to monoamine oxidase B and their metabolic pathways
The origin of specificity and insight into recognition between an aminoacyl carrier protein and its partner ligase
Insight into recognition between aminoacyl carrier protein and its binding partner
Isolation, biochemical characterization and anti-bacterial activity of BPIFA2 protein
A single amino acid substitution affects the substrate specificity of the seryl-tRNA synthetase homologue
Nobelova nagrada za kemiju za 2013. godinu
Substrate selectivity of atypical methanogenic-type Seryl-tRNA synthetases-computational approach
A. Maršavelski, I. Sabljić, D. Sugimori, B. Kojić-Prodić, The substrate selectivity of the two homologous SGNH hydrolases from Streptomyces bacteria: Molecular dynamics and experimental study, International Journal of Biological Macromolecules (2020) 158: 222-230
A. Palcic, S. Babić, A. Maršavelski, M. Galić, N. Topić Popović, I. Strunjak Perović, R. Čož-Rakovac, J. Bronić, V. Valtchev; Nanosized zeolite beta - determining the safety of usage by zebrafish Danio rerio embryos, Microporous and Mesoporous Materials (2020) 299, 110103
A. Maršavelski, D. Petrović, P. Bauer, R. Vianello, S. C. L. Kamerlin; Empirical Valence Bond Simulations Suggest a Direct Hydride Transfer Mechanism for Human Diamine Oxidase, ACS Omega (2018), 3: 3665–3674.
I. Leščić Ašler, Z. Štefanić, A. Maršavelski, R. Vianello and B. Kojić-Prodić; The Catalytic Dyad in the SGNH Hydrolase Superfamily: In-depth Insight into Structural Parameters Tuning Catalytic Process of Extracellular Lipase from Streptomyces rimosus, ACS Chemical Biology (2017), 12: 1928–1936.
A. Maršavelski; R. Vianello; “What a difference a methyl group makes - the selectivity of monoamine oxidase B towards histamine and N-methylhistamine”, Chemistry - A European Journal (2017), 23: 2915–2925.
R. J. Schwamm, R. Vianello, A. Maršavelski, M. Á. García, R. M. Claramunt, I. Alkorta, J. Saame, I. Leito, C. M. Fitchett, A. J. Edwards, and M. P. Coles; “15N NMR Spectroscopy, X-ray and Neutron Diffraction, Quantum-Chemical Calculations, and UV/vis-Spectrophotometric Titrations as Complementary Techniques for the Analysis of Pyridine-Supported Bicyclic Guanidine Superbases", Journal of Organic Chemistry, (2016), 81: 7612–7625.
A. Maršavelski; “A novel antimicrobial target—expanded and revisited mode of action of pantothenamides”, RSC advances, (2016), 6: 44888-44895.
M. Kržan, R. Vianello, A. Maršavelski, M. Repič, M. Zakšek, K. Kotnik, E. Fijan and J. Mavri; “The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands”, PLOS ONE, (2016), 11(5):e0154002.
Đ. Škalamera, E. Sanders, R. Vianello, A. Maršavelski, A. Pevec, I. Turel and S. I. Kirin; “Synthesis and characterization of ML and ML2 metal complexes with amino acid substituted bis(2-picolyl)amine ligands”, Dalton Transactions, (2016), 45: 2845-2858.
A. Maršavelski, V. Smrečki, R. Vianello, M. Žinić, A. Moguš-Milanković and A. Šantić; “Supramolecular Ionic-Liquid Gels with High Ionic Conductivity”, Chemistry - A European Journal (2015), 21: 12121–12128.
A. Maršavelski, M. Močibob, I. Gruić-Sovulj, R. Vianello; “The origin of specificity and insight into recognition between aminoacyl carrier protein and its partner ligase”, Physical Chemistry Chemical Physics (2015), 17: 19030-19038.
A. Maršavelski, S. Lesjak, M. Močibob, I. Weygand-Đurašević, S. Tomić; “A single amino acid substitution affects the substrate specificity of the seryl-tRNA synthetase homologue”, Molecular BioSystems (2014), 10: 3207-3216.
V. Prokopović, M. Popović, U. Anđelković, A. Maršavelski, B. Rasković, M. Gavrović-Jankulović, N. Polović; “Isolation, biochemical characterization and anti-bacterial activity of BPIFA2 protein”, Archives of Oral Biology (2014), 59: 302-309.
Hrvatsko biofizičko društvo
Hrvatska kristalografska zajednica
Hrvatsko društvo za biokemiju i molekularnu biologiju
Pristupačnost
