1. komponenta

Lecture type	Total
Lectures	15

* Load is given in academic hour (1 academic hour = 45 minutes)

Surface-enhanced vibrational spectroscopy (SEVS) - methods of qualitative and quantitative analysis of molecules close to or bound to the metallic nanostructured surface. Structural sensitivity - vibrational spectrum as molecular fingerprint. Analytical sensitivity - signal enhancement with respect to the normal vibrational methods: up to 10E3 for the techniques of the surface-enhanced infrared spectroscopy, up to 10E12 for the techniques of the surface-enhanced Raman spectroscopy. Selectivity - determined by the analyte structure and properties of the metallic surface. Mechanisms of the vibrational signal enhancement: electromagnetic mechanism and chemical mechanism. Surface selection rules. Types, preparation and properties of the metallic nanostructured substrates essential for observation of the surface-enhanced vibrational signal. Analysis and interpretation of the spectra. Application: structural characterization of ultra-thin films and assembled molecular layers, in-situ monitoring of photochemical, catalytic and electrochemical reactions, study of biomolecules, e.g. specific DNA sequences, nucleic acids, phospholipids and proteins, as well as complex biological structures, such as cells and microorganisms., design and development of sensors and biosensors, detection of pollutants, analysis of pharmaceutical substances and detection of analyte when coupled with the separation techniques (capillary electrophoresis, chromatography).
Principle and application of the following techniques of the linear and non-linear surface-enhanced vibrational spectroscopy: surface-enhanced infrared absorption (SEIRA), surface-enhanced Raman scattering (SERS), surface-enhanced resonance Raman scattering (SERRS), surface-enhanced Raman optical activity (SEROA), surface-enhanced hyper-Raman scattering (SEHRS), surface-enhanced coherent anti-Stokes Raman scattering (SECARS).
DEVELOPMENT OF GENERAL AND SPECIFIC COMPETENCES: Acquiring knowledge on modern vibrational spectroscopy methods with particular emphasis on development of the techniques for increasing analytical sensitivity of the vibrational spectroscopic methods.
DESCRIPTION OF INSTRUCTIONS METHODS: lectures, consultations

1. OBLIGATORY LITERATURE:
   R. Aroca, Surface-enhanced Vibrational Spectroscopy, John Wiley & Sons Ltd., Chichester, 2006.
   S. Schlucker (ur.), Surface Enahnced Raman Spectroscopy: Analytical, Biophysical and Life Science Applications, WILEY-VCH Verlag & Co. KGaA, Weinheim, 2011.
   S. Abdali, E. W. Blanch, Surface enhanced Raman optical activity (SEROA), Chem. Soc. Rev. 37 (2008) 980-992.
   D. V. Chulhai, Z. Hu, J. E. Moore, X. Chen, L. Jensen, Theory of linear and nonlinear surface-enhanced vibrational spectroscopies, Annu. Rev. Phys. Chem. 67 (2016) 23.1-23.24.
   S. Boujday, M- l. de la Chapelle, J. Srajer, W. Knoll, Enhanced vibrational spectroscopies as tools for small molecule biosensing, Sensros 15 (2015) 21239-21264.

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