COURSE CONTENT:
Role of metals in biological systems. Biomineralization, Structure-property relationship. Uptake, transport and storage of metals in organisms (metalloproteins and nonproteins in the role of transport and storage). Biological role of Fe, Co, Zn, Ni, Mo, W, V, Cr and Mn in metalloproteins. Selected metalloproteins as representatives of characteristic types of catalytic mechanisms. Alkaline earth metal ions: catalysis and regulation. Alkaline and alkaline earth metal ions as electrolytes. Toxic metals and nonmetals. Inorganic radionuclides in diagnostics and radiotherapy. Chemotherapy with compounds of nonessential elements.
LEARNING OUCOMES:
- to sketch diatomic molecular orbital diagrams; to differentiate primary, secondary, tertiary and quaternary structure of a protein
-to compare minerals and biominerals; to explain processes of nucleation and crystal growth
- to explain the basic principles of transport systems (of metal ions); to list proteins which participate in transport and storage of metal ions; to explain the role of ferritin
- to compare Weiss and Pauling model of oxygen binding; to explain factors which influence on the haemoglobin diamagnetism; to illustrate hemocyanin active site in oxy- and deoxy-form
- to explain the role of heme-proteins in electron transfer (reactions); to draw Fe-S centres found in proteins
- to differentiate vitamins according to their shape and solubility in water/fat; to differentiate corrin and porphyrin ring; to compare chemical reactions in which cobalamin participates
- to compare proteins which contain copper and iron ions; to classify proteins which contain copper ions according to coordination geometry and active site composition
- to differentiate the role of zinc ions in proteins and to give examples of these proteins
- to explain the role of the Mo-dependant nitrogenise; to draw a nitrogenase active site
- to draw active site of enolase; to draw EF-hand; to differentiate aqua- and macrocyclic complexes of alkali and alkaline earth elements; to compare synthetic and natural ionophores; to differentiate ionic channels and pumps
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- W. Kaim, B. Schwederski, Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Wiley, Chichester, 1994, ISBN 0-471-94369-x.
- D. E. Fenton, Biocoordination Chemistry, Oxford University Press, Oxford, UK, 2002
- I. Bertini, H. B. Gray, E. I. Stiefel i J. S. Valentine, Biological Inorganic Chemistry, Univ. Science Books, Sausalito, California, SAD, 2007
- J.J.R. Frausto da Silva, R.J.P. Williams: The Biological Chemistry of the Elements: the Inorganic Chemistry of Life, Oxford Univ. Press, Oxford 1994, ISBN 0 19 855598 3
- http://www.rcsb.org/pdb/home/home.do
http://www.proteopedia.org/wiki/index.php/Main_Page
- R. M. Roat-Malone, Bioinorganic Chemistry, A Short Course, J. Wiley & Sons, New Jersey, USA, 2002
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