COURSE CONTENT:
1. Chemical and biological foundations of biochemistry.
2. Protein composition and structure: amino acids.
3. Protein composition and structure: primary, secondary, tertiary and quaternary structure, denaturation and folding.
4. Examples of protein structure and function: myoglobin and hemoglobin.
5. Methods in protein research.
6. Enzymes: basic concepts, kinetics (Michaelis-Menten model), inhibition.
7. Catalytic strategies of enzmyes: chymotrypsin example.
8. Regulatory strategies: allosteric regulation, isoenzymes, phosphorylation/dephosphorylation, proteolytic activation.
9. Composition and function of cellular membranes.
10. Nucleic acid structure and role in transmission of genetic information.
11. DNA replication and repair.
12. RNA synthesis and processing.
13. Protein biosynthesis.
14. Control of gene expression in prokaryotes and eukaryotes.
Seminars will comprise solving of the problem and numerical questions that accompany each lecture.
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