|Public phone number:||+385 1 4606 235|
|Internal phone number:||6235|
|Department:||Division of Biochemistry|
|PhD graduation year:||2012|
|Employed in this institution since:||2006|
integrated undergraduate and graduate
Education at Department of Biology, Faculty of Science, University of Zagreb: Diploma thesis (Molecular Biology, 2006.); Doctoral thesis (Biology, 2012.).
Affiliation and current position: Division of Biochemistry, Department of Chemistry, Faculty of Science, University of Zagreb; Assistant professor (2016–).
Previous positions: Assistant (2006 – 2012), Division of Biochemistry, Department of Chemistry, Faculty of Science, University of Zagreb
Senior Assistant (2012 – 2016), Division of Biochemistry, Department of Chemistry, Faculty of Science, University of Zagreb.
Visits to foreign research and education institutions: 2014 European Molecular Biology Laboratory, Grenoble (duration: thrice one month)
2015 Proteome Center, University of Tuebingen (duration: one month)
Research interest: Proofreading of aminoacyl-tRNA synthetases, enzyme kinetics, thermodynamics, molecular evolution
Scientific papers: co-author of 11 scientific papers in journals indexed in Web of Science database and 1 professional paper
Awards and recognitions and memberships: Member of the Croatian Chemical Society and Croatian Society of Biochemistry and Molecular Biology
Participation in research projects: Structural diversity of seryl-tRNA synthetases and the accuracy of protein synthesis, funded by the Croatian Ministry of Science, Education and Sports (PI: Ivana WeygandĐurašević, 2007-2011) Mechanism of proofreading by class I aminoacyl-tRNA synthetases, funded by NIH/FIRCA (PI: Ita Gruić-Sovulj and John J. Perona, 2008-2011) Mapping of the isoleucyl-tRNA synthetase active site aimed to develop new inhibitors, funded by the Adris Foundation (PI: Ita Gruić-Sovulj, 2011-2013) The origin of amino acid specificity in editing class I aminoacyl-tRNA synthetases and cellular requirements for proofreading, funded by the Unity through Knowledge Fund (PI: Ita Gruić-Sovulj, 2013-2015) Macromolecular interactions in protein biosynthesis, INTEGRA-LIFE, funded by the European Union’s Seventh Framework Programme for research (PI: Ita Gruić-Sovulj, 2013-2016) Role of translational quality control mechanisms in maintaining the functional Escherichia coli proteome, funded by MZOŠ and DAAD (PI: Ita Gruić Sovulj and Boris Maček, 2014- 2015).
Note: this list of papers is located in an maintained by the Ruđer Bošković Institute which is in charge of the Croatian Scientific Bibliography Database (CROSBI). This link will take you to the appropriate CROSBI page of this person, containing a list of papers they have themselves entered in the database.
Dulic M, Cvetesic N, Zivkovic I, Palencia A, Cusack S, Bertosa B, Gruic-Sovulj, I, Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase, Journal of molecular biology, 430 (2018), 1; 1-16.
Voller J-S, Dulic M, Gerling- Driessen UIM, Biava H, Baumann T, Budisa N, Gruic-Sovulj I, Koksch B, Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation, ACS Central Science, 3 (2017), 73-80
Cvetesic N, Dulic M, Bilus M, Sostaric N, Lenhard B, Gruic- Sovulj I, Naturally Occurring Isoleucyl-tRNA Synthetase without tRNA-dependent Pre-transfer Editing, The Journal of biological chemistry, 291 (2016), 8618-8631
Dulic M, Perona JJ, Gruic-Sovulj I, Determinants for tRNA-dependent pre-transfer editing in the synthetic site of isoleucyl-tRNA synthetase, Biochemistry 53 (2014), 6189-6198.
Dulic M, Cvetesic N, Perona JJ, Gruic-Sovulj I, Partitioning of tRNA-dependent Editing between Pre- and Post-transfer Pathways in Class I Aminoacyl-tRNA Synthetases, J Biol Chem, 285 (2010), 23799-23809.